Article

Targeting Noncanonical TEAD Axis to Overcome DNA Repair-Driven Chemoresistance

2026-04-13

Abstract excerpt

<h4>Summary</h4> How transcription factors contribute to DNA damage repair (DDR) independent of canonical gene regulation remains poorly understood. Here, we show that DNA double-strand break (DSB) triggers a functional state transition in TEAD, disengaging it from YAP-dependent transcription and translocating it to DNA lesions as a chromatin-associated DDR factor. Upon genotoxic stress, TEAD is rapidly recruited...

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Literature Corpus work: f1d80a14-765c-5170-9f34-5f30195af1a8
DOI: 10.64898/2026.04.09.717588

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