Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-Genome Sequencing Reveals Rare Off-Target Mutations in MC1R-Edited Pigs Generated by Using CRISPR-Cas9 and Somatic Cell Nuclear Transfer.

The CRISPR journal - 1 Feb 2024

Li Zhenyang, Lan Jin, Shi Xuan, Lu Tong, Hu Xiaoli, Liu Xiaohong, Chen Yaosheng, He Zuyong

Abstract excerpt

The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system has been widely used to create animal models for biomedical and agricultural use owing to its low cost and easy handling. However, the occurrence of erroneous cleavage (off-targeting) may raise certain concerns for the practical application of the CRISPR-Cas9 system. In this study, we created a melanocortin 1 receptor (MC1R)-edited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Gene Editing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to INDEL Mutation

Share to Mutation

Share to Receptor, Melanocortin, Type 1

Source

Identifiers

PMID: 38353621
DOI: 10.1089/crispr.2023.0034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-Genome Sequencing Reveals Rare Off-Target Mutations in MC1R-Edited Pigs Generated by Using CRISPR-Cas9 and Somatic Cell Nuclear Transfer.PMID 38353621Read ↗

Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer.Semantic proximity Read ↗

Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos.Semantic proximity Read ↗

Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA.Semantic proximity Read ↗

Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes.Semantic proximity Read ↗

Generation of an MC3R knock-out pig by CRSPR/Cas9 combined with somatic cell nuclear transfer (SCNT) technologySemantic proximity Read ↗

Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs.Semantic proximity Read ↗

Genome editing for disease resistance in pigs and chickensSemantic proximity Read ↗

Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12iMax.Semantic proximity Read ↗

Targeted gene knock-in by CRISPR/Cas ribonucleoproteins in porcine zygotes.Semantic proximity Read ↗

Efficient Generation of Myostatin Mutations in Pigs Using the CRISPR/Cas9 System.Semantic proximity Read ↗

Pig Coat Color Manipulation by MC1R Gene Editing.Semantic proximity Read ↗

Genome-wide Genetic Mutations Accumulated in Pigs Genome-edited for Xenotransplantation and Their Filial Generation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.