Article
Pig Coat Color Manipulation by MC1R Gene Editing.
International journal of molecular sciences - 8 Sept 2022
Zhong Haiwen, Zhang Jian, Tan Cheng, Shi Junsong, Yang Jie, Cai Gengyuan, Wu Zhenfang, Yang Huaqiang
Abstract excerpt
Black coat color in pigs is determined by the dominant E allele at the MC1R locus. Through comparing MC1R gene sequences between recessive e and dominant ED1 alleles, we identified four missense mutations that could affect MC1R protein function for eumelanin synthesis. With the aim of devising a genetic modification method for pig coat color manipulation, we mutated the e allele in the Duroc breed to the dominant...
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