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Article

Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer.

Cellular and molecular life sciences : CMLS - 1 Mar 2015

Zhou Xiaoqing, Xin Jige, Fan Nana, Zou Qingjian, Huang Jiao, Ouyang Zhen, Zhao Yu, Zhao Bentian, Liu Zhaoming, Lai Sisi, Yi Xiaoling, Guo Lin, Esteban Miguel A, Zeng Yangzhi, Yang Huaqiang, Lai Liangxue

Abstract excerpt

The domestic pig has been widely used as an important large animal model. Precise and efficient genetic modification in pig provides a great promise in biomedical research. Recently, clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system has been successfully used to produce many gene-targeted animals. However, these animals have been generated by co-injection of Cas9...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25274063
DOI: 10.1007/s00018-014-1744-7
PMCID: PMC11113635

Genes

PINK1
TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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