Article
Genome-wide Genetic Mutations Accumulated in Pigs Genome-edited for Xenotransplantation and Their Filial Generation.
Genomics, proteomics & bioinformatics - 28 Oct 2025
Huo 霍学云 Xueyun, Sun 孙先辉 Xianhui, Xing 邢向阳 Xiangyang, Lu 路静 Jing, Zhang 张晶晶 Jingjing, Jiang 蒋艳艳 Yanyan, Zhu 朱筱 Xiao, Li 李长龙 Changlong, Lv 吕建祎 Jianyi, Guo 郭萌 Meng, Cao 曹立雪 Lixue, Liu 刘欣 Xin, Chen 陈振文 Zhenwen, Pan 潘登科 Dengke, He 何顺民 Shunmin, Zhang 张晨 Chen, Du 杜小燕 Xiaoyan
Abstract excerpt
Although xenotransplantation has been revolutionized by the development of genome-edited pigs, it is still unknown whether these pigs and their offspring remain genomically stable. Here, we showed that GGTA1-knockout (GTKO) pigs accumulated an average of 1205 genome-wide genetic mutations, and their filial 1 (F1) offspring contained an average of 18 de novo mutations compared with wild-type controls and their...
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