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Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12iMax.

Science China. Life sciences - 1 Mar 2024

Ren Jilong, Hai Tang, Chen Yangcan, Sun Ke, Han Zhiqiang, Wang Jing, Li Chongyang, Wang Qingwei, Wang Leyun, Zhu Huabing, Yu Dawei, Li Wei, Zhao Shanjiang

Abstract excerpt

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated gene (Cas) system is continually optimized to achieve the most efficient gene editing effect. The Cas12iMax, a Cas12i variant, exhibits powerful DNA editing activity and enriches the gene editing toolbox. However, the application of Cas12iMax in large domestic animals has not yet been reported. To verify the efficiency and...

Topics

Animals
Cattle
Swine
CRISPR-Cas Systems
Livestock
Gene Editing
Phenotype
DNA

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37987939
DOI: 10.1007/s11427-023-2407-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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