Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Template-specific optimization of NGS genotyping pipelines reveals allele-specific variation in MHC gene expression.

Molecular ecology resources - 1 May 2024

Efstratiou Artemis, Gaigher Arnaud, Künzel Sven, Teles Ana, Lenz Tobias L

Abstract excerpt

Using high-throughput sequencing for precise genotyping of multi-locus gene families, such as the major histocompatibility complex (MHC), remains challenging, due to the complexity of the data and difficulties in distinguishing genuine from erroneous variants. Several dedicated genotyping pipelines for data from high-throughput sequencing, such as next-generation sequencing (NGS), have been developed to tackle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA, Complementary
Share to Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Genotyping Techniques

Share to Haplotypes

Share to High-Throughput Nucleotide Sequencing

Source

Identifiers

PMID: 38332480
DOI: 10.1111/1755-0998.13935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Template-specific optimization of NGS genotyping pipelines reveals allele-specific variation in MHC gene expression.PMID 38332480Read ↗

Stepwise threshold clustering: a new method for genotyping MHC loci using next-generation sequencing technology.Semantic proximity Read ↗

MHC genotyping of non-model organisms using next-generation sequencing: a new methodology to deal with artefacts and allelic dropout.Semantic proximity Read ↗

High-Throughput Sequencing of the Major Histocompatibility Complex following Targeted Sequence Capture.Semantic proximity Read ↗

Large-scale genotyping of highly polymorphic loci by next-generation sequencing: how to overcome the challenges to reliably genotype individuals?Semantic proximity Read ↗

RSCA genotyping of MHC for high-throughput evolutionary studies in the model organism three-spined stickleback Gasterosteus aculeatus.Semantic proximity Read ↗

Assessing a single targeted next generation sequencing for human leukocyte antigen typing protocol for interoperability, as performed by users with variable experience.Semantic proximity Read ↗

Uncovering novel MHC alleles from RNA-Seq data: Expanding the spectrum of MHC class I alleles in sheepSemantic proximity Read ↗

NEXT-scASV: a Nextflow pipeline for allele-specific variant calling from single-cell RNA-seq data.Semantic proximity Read ↗

PCR Strategies for Complete Allele Calling in Multigene Families Using High-Throughput Sequencing Approaches.Semantic proximity Read ↗

Prediction of HLA genotypes from single-cell transcriptome dataSemantic proximity Read ↗

Prediction of HLA genotypes from single-cell transcriptome data.Semantic proximity Read ↗

Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.