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Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data.

BMC genomics - 9 May 2023

Claeys Arne, Merseburger Peter, Staut Jasper, Marchal Kathleen, Van den Eynden Jimmy

Abstract excerpt

BACKGROUND: The Human Leukocyte Antigen (HLA) genes are a group of highly polymorphic genes that are located in the Major Histocompatibility Complex (MHC) region on chromosome 6. The HLA genotype affects the presentability of tumour antigens to the immune system. While knowledge of these genotypes is of utmost importance to study differences in immune responses between cancer patients, gold standard, PCR-derived...

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Identifiers

PMID: 37161318
DOI: 10.1186/s12864-023-09351-z
PMCID: PMC10170851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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