Article
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Nature structural & molecular biology - 1 Apr 2024
Hoppe Nicholas, Harrison Simone, Hwang Sun-Hee, Chen Ziwei, Karelina Masha, Deshpande Ishan, Suomivuori Carl-Mikael, Palicharla Vivek R, Berry Samuel P, Tschaikner Philipp, Regele Dominik, Covey Douglas F, Stefan Eduard, Marks Debora S, Reiter Jeremy F, Dror Ron O, Evers Alex S, Mukhopadhyay Saikat, Manglik Aashish
Abstract excerpt
The orphan G protein-coupled receptor (GPCR) GPR161 plays a central role in development by suppressing Hedgehog signaling. The fundamental basis of how GPR161 is activated remains unclear. Here, we determined a cryogenic-electron microscopy structure of active human GPR161 bound to heterotrimeric Gs. This structure revealed an extracellular loop 2 that occupies the canonical GPCR orthosteric ligand pocket....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.