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Article

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.

The Journal of experimental medicine - 5 Mar 2018

Ackerman Sarah D, Luo Rong, Poitelon Yannick, Mogha Amit, Harty Breanne L, D'Rozario Mitchell, Sanchez Nicholas E, Lakkaraju Asvin K K, Gamble Paul, Li Jun, Qu Jun, MacEwan Matthew R, Ray Wilson Zachary, Aguzzi Adriano, Feltri M Laura, Piao Xianhua, Monk Kelly R

Abstract excerpt

Myelin is a multilamellar sheath generated by specialized glia called Schwann cells (SCs) in the peripheral nervous system (PNS), which serves to protect and insulate axons for rapid neuronal signaling. In zebrafish and rodent models, we identify GPR56/ADGRG1 as a conserved regulator of PNS development and health. We demonstrate that, during SC development, GPR56-dependent RhoA signaling promotes timely radial...

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Source

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Identifiers

PMID: 29367382
DOI: 10.1084/jem.20161714
PMCID: PMC5839751

Genes

ADGRG1

Provenance

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