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Article

Downstream signalling of the disease-associated mutations on GPR56/ADGRG1.

Basic & clinical pharmacology & toxicology - 1 Oct 2023

Cevheroğlu Orkun, Demir Nil, Kesici Mehmet Seçkin, Özçubukçu Salih, Son Çağdaş D

Abstract excerpt

GPR56/ADGRG1 is an adhesion G protein-coupled receptor (GPCR) and mutations on this receptor cause cortical malformation due to the over-migration of neural progenitor cells on brain surface. At pial surface, GPR56 interacts with collagen III, induces Rho-dependent activation through Gα12/13 and inhibits the neuronal migration. In human glioma cells, GPR56 inhibits cell migration through Gαq/11 -dependent Rho...

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Identifiers

PMID: 37056198
DOI: 10.1111/bcpt.13873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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