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Article

Decoding the structure of GPR151 via NELiS.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2026

Wang Yumeng, Fan Luyu, Song Qianqian, Li Yaning, Jin Jiayu, Zhao Qiaoyu, Gu Weijie, Shi Xiangyi, Li Dianfan, Cong Yao, Wang Sheng

Abstract excerpt

Structure determination of orphan G protein-coupled receptors (GPCRs) is hindered by lack of known ligands and their inherent instability during purification. Conventional thermostability screening requires ligands or purified protein, limiting its utility for orphan GPCRs. Here, we present the Nb6-Enabled Ligand-Free Stabilization Platform (NELiS)-a ligand- and purification-independent method for identifying...

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Identifiers

PMID: 42085164
DOI: 10.1073/pnas.2534234123
PMCID: PMC13167728

Genes

GPR151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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