Article
The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation.
Developmental biology - 1 Jun 2015
Li Bo I, Matteson Paul G, Ababon Myka F, Nato Alejandro Q, Lin Yong, Nanda Vikas, Matise Tara C, Millonig James H
Abstract excerpt
The vacuolated lens (vl) mouse mutation arose on the C3H/HeSnJ background and results in lethality, neural tube defects (NTDs) and cataracts. The vl phenotypes are due to a deletion/frameshift mutation in the orphan GPCR, Gpr161. A recent study using a null allele demonstrated that Gpr161 functions in primary cilia and represses the Shh pathway. We show the hypomorphic Gpr161(vl) allele does not severely affect...
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