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Article

Cryo‐EM structure of orphan G protein‐coupled receptor GPR21

25 Jan 2023

Abstract excerpt

GPR21 belongs to class A orphan G protein-coupled receptor (GPCR). The endogenous ligands for human GPR21 remain unidentified. GPR21 expression is associated with developing type 2 diabetes (T2DM), a multifactorial metabolic disease caused by pancreatic β-cell dysfunction, decreasing insulin production, insulin resistance, and obesity. Animal studies suggested that GPR21 is a potential therapeutic target for T2DM...

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PMID: 36721851
DOI: 10.1002/mco2.205

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