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Article

Feedback control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish.

Development (Cambridge, England) - 17 Feb 2021

Tschaikner Philipp M, Regele Dominik, Röck Ruth, Salvenmoser Willi, Meyer Dirk, Bouvier Michel, Geley Stephan, Stefan Eduard, Aanstad Pia

Abstract excerpt

Hedgehog (Hh) ligands act as morphogens to direct patterning and proliferation during embryonic development. Protein kinase A (PKA) is a central negative regulator of Hh signalling, and in the absence of Hh ligands, PKA activity prevents inappropriate expression of Hh target genes. The orphan G-protein-coupled receptor Gpr161 contributes to the basal Hh repression machinery by activating PKA. Gpr161 acts as an...

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Identifiers

PMID: 33531430
DOI: 10.1242/dev.192443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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