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Article

Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.

The Journal of cell biology - 28 Mar 2016

Pal Kasturi, Hwang Sun-Hee, Somatilaka Bandarigoda, Badgandi Hemant, Jackson Peter K, DeFea Kathryn, Mukhopadhyay Saikat

Abstract excerpt

Dynamic changes in membrane protein composition of the primary cilium are central to development and homeostasis, but we know little about mechanisms regulating membrane protein flux. Stimulation of the sonic hedgehog (Shh) pathway in vertebrates results in accumulation and activation of the effector Smoothened within cilia and concomitant disappearance of a negative regulator, the orphan G protein-coupled...

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PMID: 27002170
DOI: 10.1083/jcb.201506132
PMCID: PMC4810300

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