Article

Structural basis for adhesion G protein-coupled receptor Gpr126 function

2019-10-17

Abstract excerpt

Many drugs target the extracellular regions (ECRs) of cell-surface receptors. The large and alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key functions in diverse biological processes including neurodevelopment, embryogenesis, and tumorigenesis. However, their structures and mechanisms of action remain unclear, hampering drug development. The aGPCR Gpr126/Adgrg6 regulates Schwann...

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Literature Corpus work: 7d438317-0d65-56e6-bd7f-4621a01e230e
DOI: 10.1101/805515

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