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Article

Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks.

Nucleic acids research - 24 Apr 2024

Audry Julien, Zhang Haitao, Kerr Carly, Berkner Kathleen L, Runge Kurt W

Abstract excerpt

Telomeres protect chromosome ends and are distinguished from DNA double-strand breaks (DSBs) by means of a specialized chromatin composed of DNA repeats bound by a multiprotein complex called shelterin. We investigated the role of telomere-associated proteins in establishing end-protection by studying viable mutants lacking these proteins. Mutants were studied using a Schizosaccharomyces pombe model system that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38321948
DOI: 10.1093/nar/gkae044
PMCID: PMC11040153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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