Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mre11 complex links sister chromatids to promote repair of a collapsed replication fork.

Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2018

Zhu Min, Zhao Hongchang, Limbo Oliver, Russell Paul

Abstract excerpt

Collapsed replication forks, which are a major source of DNA double-strand breaks (DSBs), are repaired by sister chromatid recombination (SCR). The Mre11-Rad50-Nbs1 (MRN) protein complex, assisted by CtIP/Sae2/Ctp1, initiates SCR by nucleolytically resecting the single-ended DSB (seDSB) at the collapsed fork. The molecular architecture of the MRN intercomplex, in which zinc hooks at the apices of long Rad50...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatids
Share to Chromosomes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Fungal

Share to DNA Replication

Share to Exodeoxyribonucleases

Share to Multiprotein Complexes

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 30104346
DOI: 10.1073/pnas.1808189115
PMCID: PMC6126713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mre11 complex links sister chromatids to promote repair of a collapsed replication fork.PMID 30104346Read ↗

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairSemantic proximity Read ↗

The MRN complex in double-strand break repair and telomere maintenance.Semantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.Semantic proximity Read ↗

Turning the Mre11/Rad50 DNA repair complex on its head: lessons from SMC protein hinges, dynamic coiled-coil movements and DNA loop-extrusion?Semantic proximity Read ↗

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.Semantic proximity Read ↗

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners.Semantic proximity Read ↗

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP.Semantic proximity Read ↗

Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.Semantic proximity Read ↗

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and RepairSemantic proximity Read ↗

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Semantic proximity Read ↗

The Mammalian Mre11-Rad50-Nbs1 Protein Complex: Integration of Functions in the Cellular DNA–Damage ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.