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Article

Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.

The EMBO journal - 1 Dec 2010

Dewar James M, Lydall David

Abstract excerpt

Essential telomere 'capping' proteins act as a safeguard against ageing and cancer by inhibiting the DNA damage response (DDR) and regulating telomerase recruitment, thus distinguishing telomeres from double-strand breaks (DSBs). Uncapped telomeres and unrepaired DSBs can both stimulate a potent DDR, leading to cell cycle arrest and cell death. Using the cdc13-1 mutation to conditionally 'uncap' telomeres in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21045806
DOI: 10.1038/emboj.2010.267
PMCID: PMC3020640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.PMID 21045806Read ↗

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Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Linear chromosome maintenance in the absence of essential telomere-capping proteins.Semantic proximity Read ↗

Mrc1, a non-essential DNA replication protein, is required for telomere end protection following loss of capping by Cdc13, Yku or telomerase.Semantic proximity Read ↗

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Semantic proximity Read ↗

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres.Semantic proximity Read ↗

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.Semantic proximity Read ↗

MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants.Semantic proximity Read ↗

DDK has a primary role in processing stalled replication forks to initiate downstream checkpoint signalingSemantic proximity Read ↗

TEN1 is essential for CDC13-mediated telomere capping.Semantic proximity Read ↗

The Mph1 helicase can promote telomere uncapping and premature senescence in budding yeast.Semantic proximity Read ↗

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