Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres.

eLife - 3 Aug 2017

Strecker Jonathan, Stinus Sonia, Caballero Mariana Pliego, Szilard Rachel K, Chang Michael, Durocher Daniel

Abstract excerpt

DNA double-strand breaks (DSBs) and short telomeres are structurally similar, yet they have diametrically opposed fates. Cells must repair DSBs while blocking the action of telomerase on these ends. Short telomeres must avoid recognition by the DNA damage response while promoting telomerase recruitment. In Saccharomyces cerevisiae, the Pif1 helicase, a telomerase inhibitor, lies at the interface of these end-fate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Fungal

Share to DNA Helicases

Share to Gene Expression Regulation, Fungal

Share to Telomerase

Share to Telomere

Share to Telomere-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28826474
DOI: 10.7554/eLife.23783
PMCID: PMC5595431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres.PMID 28826474Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.Semantic proximity Read ↗

Telomere shortening triggers a feedback loop to enhance end protection.Semantic proximity Read ↗

Telomeres: Structures in need of unwindingSemantic proximity Read ↗

Bring It to an End: Does Telomeres Size Matter?Semantic proximity Read ↗

Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at TelomeresSemantic proximity Read ↗

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes endSemantic proximity Read ↗

Telomeres and the DNA damage response: why the fox is guarding the henhouse.Semantic proximity Read ↗

To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand BreaksSemantic proximity Read ↗

The many faces of the helicase RTEL1 at telomeres and beyond.Semantic proximity Read ↗

Pif1p helicase, a catalytic inhibitor of telomerase in yeast.Semantic proximity Read ↗

All things must end: telomere dynamics in yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.