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Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase Recruitment

27 Aug 2009

Abstract excerpt

The checkpoint kinases ATM and ATR are redundantly required for maintenance of stable telomeres in diverse organisms, including budding and fission yeasts, Arabidopsis, Drosophila, and mammals. However, the molecular basis for telomere instability in cells lacking ATM and ATR has not yet been elucidated fully in organisms that utilize both the telomere protection complex shelterin and telomerase to maintain...

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PMID: 19714219
DOI: 10.1371/journal.pgen.1000622

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Research trail→

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Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase RecruitmentPMID 19714219Read ↗

Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.Semantic proximity Read ↗

Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast.Semantic proximity Read ↗

Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.Semantic proximity Read ↗

Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.Semantic proximity Read ↗

A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.Semantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresSemantic proximity Read ↗

<i>Drosophila</i> ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenanceSemantic proximity Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

Fission yeast Ccq1 is a modulator of telomerase activity.Semantic proximity Read ↗

Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.Semantic proximity Read ↗

Fission yeast RPA–TERT–Tpz1 <sup>TPP1</sup> complex promotes telomere extension and suppresses telomere recombinationSemantic proximity Read ↗

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