Article
The telomere protein Taz1 is required to prevent and repair genomic DNA breaks.
Molecular cell - 1 Feb 2003
Miller Kyle M, Cooper Julia Promisel
Abstract excerpt
One fundamental function of telomeres is to prevent the ends of chromosomes from being sensed and treated as DNA damage. Here we present evidence for additional roles of telomeres in promoting proper chromosome segregation and DNA repair. We find that the fission yeast telomere protein Taz1p is required for cell cycle progression at 20 degrees C, a temperature at which taz1Delta cells exhibit a G(2)/M DNA damage...
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