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Article

Fission yeast Ccq1 is a modulator of telomerase activity.

Nucleic acids research - 25 Jan 2018

Armstrong Christine A, Moiseeva Vera, Collopy Laura C, Pearson Siân R, Ullah Tomalika R, Xi Shidong T, Martin Jennifer, Subramaniam Shaan, Marelli Sara, Amelina Hanna, Tomita Kazunori

Abstract excerpt

Shelterin, the telomeric protein complex, plays a crucial role in telomere homeostasis. In fission yeast, telomerase is recruited to chromosome ends by the shelterin component Tpz1 and its binding partner Ccq1, where telomerase binds to the 3' overhang to add telomeric repeats. Recruitment is initiated by the interaction of Ccq1 with the telomerase subunit Est1. However, how telomerase is released following...

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Identifiers

PMID: 29216371
DOI: 10.1093/nar/gkx1223
PMCID: PMC5778466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fission yeast Ccq1 is a modulator of telomerase activity.PMID 29216371Read ↗

Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.Semantic proximity Read ↗

Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.Semantic proximity Read ↗

Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.Semantic proximity Read ↗

How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasisSemantic proximity Read ↗

Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase RecruitmentSemantic proximity Read ↗

Telomerase activation after recruitment in fission yeast.Semantic proximity Read ↗

Est1 protects telomeres and inhibits subtelomeric y'-element recombination.Semantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

A new telomerase RNA element that is critical for telomere elongation.Semantic proximity Read ↗

Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.Semantic proximity Read ↗

Regulation of Telomerase by Telomeric ProteinsSemantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

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