Article
Linear chromosome maintenance in the absence of essential telomere-capping proteins.
Nature cell biology - 1 Jul 2006
Zubko Mikhajlo K, Lydall David
Abstract excerpt
Telomeres were defined by their ability to cap chromosome ends. Proteins with high affinity for the structure at chromosome ends, binding the G-rich, 3' single-stranded overhang at telomeres include Pot1 in humans and fission yeast, TEBP in Oxytricha nova and Cdc13 in budding yeast. Cdc13 is considered essential for telomere capping because budding yeast that lack Cdc13 rapidly accumulate excessive...
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