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Article

Stress response silencing by an E3 ligase mutated in neurodegeneration.

Nature - 1 Feb 2024

Haakonsen Diane L, Heider Michael, Ingersoll Andrew J, Vodehnal Kayla, Witus Samuel R, Uenaka Takeshi, Wernig Marius, Rapé Michael

Abstract excerpt

Stress response pathways detect and alleviate adverse conditions to safeguard cell and tissue homeostasis, yet their prolonged activation induces apoptosis and disrupts organismal health1-3. How stress responses are turned off at the right time and place remains poorly understood. Here we report a ubiquitin-dependent mechanism that silences the cellular response to mitochondrial protein import stress. Crucial to...

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Identifiers

PMID: 38297121
DOI: 10.1038/s41586-023-06985-7
PMCID: PMC10881396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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