Article

A stress-dependent TDP-43 SUMOylation program preserves neuronal function

2024-04-13

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that the progressive accumulation of exogenous factors – such as cellular stressors – converge on TDP-43 to play a key role in disease pathogenesis. Post translational modifications such as SUMOylation play essential roles in response to such exogenous stre...

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Literature Corpus work: 299a2b41-a067-543c-a392-33c6691f8135
DOI: 10.1101/2024.04.12.589206

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