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Dual Nature of Mitochondrial Integrated Stress Response: Molecular Switches from Protection to Pathology

13 Aug 2025

Abstract excerpt

BACKGROUND: The mitochondrial integrated stress response (ISR) represents a fundamental cellular adaptation mechanism with dual protective and pathological roles. We critically analyzed current literature on ISR mechanisms, focusing on recent paradigm shifts including the 2020 discovery of the OMA1-DELE1-HRI axis, emerging controversies over context-dependent activation patterns, and the January 2025 clinical...

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PMID: 40870005
DOI: 10.3390/genes16080957

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