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Article

Context-dependent YEATS-domain inhibition enhances neuronal resilience and improves ALS phenotypes.

Neurobiology of disease - 1 Oct 2026

Lo Piccolo Luca, Panto Chansunee, Yeewa Ranchana, Yubolphan Ruedeemars, Poound Puttachat, Potikanond Saranyapin, Jantrapirom Salinee

Abstract excerpt

Neuronal loss in neurodegenerative disease is driven in part by maladaptive stress signaling and impaired adaptation to proteotoxic challenges. ENL and AF9 are YEATS-domain acyl-lysine reader proteins best characterized in leukemia, but their functions in neurons remains unclear. Here, we defined the role of the ENL/AF9 YEATS domain using complementary chemical and genetic perturbations. We applied the selective...

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Topics

Animals
Amyotrophic Lateral Sclerosis
Humans
Neurons
Drosophila Proteins
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drosophila

Drosophila melanogaster

Source

Identifiers

PMID: 42508735
DOI: 10.1016/j.nbd.2026.107549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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