Article

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

2024-11-25

Abstract excerpt

The oxidative stress response is centered on the transcription factor NRF2 and protects cells from reactive oxygen species (ROS). While ROS inhibit the E3 ligase CUL3 KEAP1 to stabilize NRF2 and elicit antioxidant gene expression, cells recovering from stress must rapidly reactivate CUL3 KEAP1 to prevent reductive stress and oxeiptosis-dependent cell death. How cells restore efficient NRF2-degradation upon ROS c...

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Literature Corpus work: 84270919-3718-5b08-99e5-46a8036ba03b
DOI: 10.1101/2024.11.25.625235

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