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Sensing, signaling and surviving mitochondrial stress

6 Jul 2021

Abstract excerpt

Mitochondrial fidelity is a key determinant of longevity and was found to be perturbed in a multitude of disease contexts ranging from neurodegeneration to heart failure. Tight homeostatic control of the mitochondrial proteome is a crucial aspect of mitochondrial function, which is severely complicated by the evolutionary origin and resulting peculiarities of the organelle. This is, on one hand, reflected by a...

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PMID: 34228161
DOI: 10.1007/s00018-021-03887-7

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