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Article

The ACE inhibitor captopril inhibits ACN-1 to control dauer formation and aging.

Development (Cambridge, England) - 1 Feb 2024

Egan Brian M, Pohl Franziska, Anderson Xavier, Williams Shoshana C, Gregory Adodo Imienreluefe, Hunt Patrick, Wang Zuoxu, Chiu Chen-Hao, Scharf Andrea, Mosley Matthew, Kumar Sandeep, Schneider Daniel L, Fujiwara Hideji, Hsu Fong-Fu, Kornfeld Kerry

Abstract excerpt

The renin-angiotensin-aldosterone system (RAAS) plays a well-characterized role regulating blood pressure in mammals. Pharmacological and genetic manipulation of the RAAS has been shown to extend lifespan in Caenorhabditis elegans, Drosophila and rodents, but its mechanism is not well defined. Here, we investigate the angiotensin-converting enzyme (ACE) inhibitor drug captopril, which extends lifespan in worms...

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Identifiers

PMID: 38284547
DOI: 10.1242/dev.202146
PMCID: PMC10911126

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ACE

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