Article

SARS-CoV-2 Entry Can Be Mimicked in <em>C. elegans</em> Expressing Human ACE2: A New Tool for Pharmacological Studies

2025-09-18

Abstract excerpt

Testing medical countermeasures for SARS-CoV-2 transmission using vertebrates can be slowed by legislation regulating animal experimentation, high costs, and ethical concerns. To overcome these challenges, we propose a new Caenorhabditis elegans strain that constitutively expresses the human angiotensin-converting enzyme 2 receptor (ACE2). This resulted in significant impairment of reproduction and a defect in pha...

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Literature Corpus work: df34f9cc-5666-589f-9a97-9c463d838dc1
DOI: 10.20944/preprints202509.1598.v1

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