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Article

APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation.

Cellular and molecular life sciences : CMLS - 27 Jan 2024

Zhang Dan, Ni Qi-Qi, Wang Shu-Yang, He Wen-Feng, Hong Ze-Xuan, Liu Hui-Ye, Chen Xiao-Hong, Chen Li-Jie, Han Fang-Yi, Zhang Ling-Jie, Li Xiao-Ming, Ding Yan-Qing, Jiao Hong-Li, Ye Ya-Ping

Abstract excerpt

The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid-liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a normal cellular state. Mutations inactivating the APC gene are found in approximately 80% of all human colorectal cancer (CRC). However, the molecular mechanism of the formation of β-catenin destruction complex...

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Identifiers

PMID: 38279052
DOI: 10.1007/s00018-023-05068-0
PMCID: PMC10817841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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