Article

Condensate screening identifies YM155 as β-catenin condensate inhibitor in colorectal cancer

2025-01-15

Abstract excerpt

<h4>ABSTRACT</h4> β-catenin is a transcriptional cofactor crucial in forming biomolecular condensates that drive WNT target gene transcription. Its pathological accumulation in the nucleus is a critical step in WNT-driven cancers, such as colorectal cancer. Disrupting β-catenin condensates is a promising cancer treatment strategy, but no clinical applications currently exist. In this study, we developed a Nanobod...

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Literature Corpus work: 50bf5da9-0b2e-5517-9118-4fafc29991c2
DOI: 10.1101/2025.01.13.632724

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