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Article

Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth.

Nature communications - 3 Feb 2022

Miete Cezanne, Solis Gonzalo P, Koval Alexey, Brückner Martina, Katanaev Vladimir L, Behrens Jürgen, Bernkopf Dominic B

Abstract excerpt

Conductin/axin2 is a scaffold protein negatively regulating the pro-proliferative Wnt/β-catenin signaling pathway. Accumulation of scaffold proteins in condensates frequently increases their activity, but whether condensation contributes to Wnt pathway inhibition by conductin remains unclear. Here, we show that the Gαi2 subunit of trimeric G-proteins induces conductin condensation by targeting a...

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Identifiers

PMID: 35115535
DOI: 10.1038/s41467-022-28286-9
PMCID: PMC8814139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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