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Article

Structural and functional insights into the lipid regulation of human anion exchanger 2.

Nature communications - 26 Jan 2024

Zhang Weiqi, Ding Dian, Lu Yishuo, Chen Hongyi, Jiang Peijun, Zuo Peng, Wang Guangxi, Luo Juan, Yin Yue, Luo Jianyuan, Yin Yuxin

Abstract excerpt

Anion exchanger 2 (AE2) is an electroneutral Na+-independent Cl-/HCO3- exchanger belongs to the SLC4 transporter family. The widely expressed AE2 participates in a variety of physiological processes, including transepithelial acid-base secretion and osteoclastogenesis. Both the transmembrane domains (TMDs) and the N-terminal cytoplasmic domain (NTD) are involved in regulation of AE2 activity. However, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38272905
DOI: 10.1038/s41467-024-44966-0
PMCID: PMC10810954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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