Structural and mechanistic insights into SLC34 phosphate import

Abstract excerpt

Dysregulation of inorganic phosphate (Pi) homeostasis contributes to metabolic disease, cancer, pathological calcification, and kidney disease. Systemic phosphate balance is regulated by SLC34 transporters that mediate renal Pi retention (SLC34A1/A3) and intestinal dietary Pi absorption (SLC34A2). SLC34s couple Pi uptake to the symport of sodium (Na + ) down its electrochemical gradient. Mutations or altered expr...

Topics

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• Amino Acid Motifs
• Amino Acid Sequence
• Binding Sites
• Familial Hypophosphatemic Rickets
• Molecular Dynamics Simulation
• Molecular Sequence Data
• Mutation
• Phosphates

Identifiers and source

Literature Corpus work

32779c32-ac38-5f7b-9cce-93f6286157c2

DOI

10.64898/2026.05.25.727688