Article
Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP2.
Nature communications - 3 Oct 2023
Lu Yishuo, Zuo Peng, Chen Hongyi, Shan Hui, Wang Weize, Dai Zonglin, Xu He, Chen Yayu, Liang Ling, Ding Dian, Jin Yan, Yin Yuxin
Abstract excerpt
BTR1 (SLC4A11) is a NH3 stimulated H+ (OH-) transporter belonging to the SLC4 family. Dysfunction of BTR1 leads to diseases such as congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy (FECD). However, the mechanistic basis of BTR1 activation by alkaline pH, transport activity regulation and pathogenic mutations remains elusive. Here, we present cryo-EM structures of human...
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