Article
Inactivation mechanisms of Na+/ HCO 3 - cotransporter NBCe1 by phosphorylation.
Communications biology - 28 Aug 2025
Wu Han, Feng Xuhui, Wang Meng, Gui Tianxiang, Fu Mingfeng, Zheng Mengmeng, Huang Zixuan, Luo Xudong, Liu Ying, Chen Li-Ming
Abstract excerpt
The solute carriers (SLC) superfamily comprises 66 families with more than 450 members. The Na+/ HCO 3 - cotransporter NBCe1 (SLC4A4) of SLC4 family plays critical roles in intracellular pH regulation and transepithelial transport of fluid and electrolytes. Here, we explored the structural mechanisms of NBCe1-A regulation by two phosphorylation modules: P-loop in the amino-terminal domain and H-loop in the...
Read the complete abstract on PubMedTopics
- Phosphorylation
- Sodium-Bicarbonate Symporters
- Humans
- HEK293 Cells
- Mutation