Article

Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger

2022-06-03

Abstract excerpt

<title>Abstract</title> <p>Pendrin SLC26A4 is an anion exchanger expressed in apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder disease associated with sensorineural hearing loss, hypothyroid goiter, and reduced blood pressure. However, its molecular structure has remained unknown limiting our understanding. Here, we determined the structures of mouse pendrin wit...

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Literature Corpus work: 4a833f16-88d7-5c3c-9ceb-65e67c602a43
DOI: 10.21203/rs.3.rs-1700736/v1

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