Article

Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger

2022-01-16

Abstract excerpt

Pendrin SLC26A4 is an anion exchanger expressed in apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder disease associated with sensorineural hearing loss, hypothyroid goiter, and reduced blood pressure. However, its molecular structure has remained unknown limiting our understanding. Here, we determined the structures of mouse pendrin with symmetric and characterist...

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Literature Corpus work: 51850e62-89a6-51d6-a376-52ffe0c93441
DOI: 10.1101/2022.01.14.476289

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