Article

Transport and InsP8 activation mechanisms of the human inorganic phosphate exporter XPR1

2024-10-05

Abstract excerpt

<h4>Summary</h4> Inorganic phosphate (Pi) has essential metabolic and structural roles in living organisms. The Pi exporter, XPR1/SLC53A1, is critical for maintaining cellular Pi homeostasis. When intercellular Pi is high, cells synthesize inositol pyrophosphate (1,5-InsP 8 ) – a signaling molecule that is required for XPR1 function. Inactivating mutations of XPR1 lead to brain calcifications causing neurologica...

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Literature Corpus work: a86f171d-e204-5c2a-beda-242eb4a8dea2
DOI: 10.1101/2024.10.04.616715

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