CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.

doi:10.1007/s00228-016-2029-x

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Article

CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.

European journal of clinical pharmacology - 1 Jun 2016

Zhu Hao-Jie, Langaee Taimour Y, Gong Yan, Wang Xinwen, Pepine Carl J, Cooper-DeHoff Rhonda M, Johnson Julie A, Markowitz John S

Abstract excerpt

PURPOSE: The majority of angiotensin-converting enzyme inhibitors (ACEIs) are synthesized as ester prodrugs that must be converted to their active forms in vivo in order to exert therapeutic effects. Hepatic carboxylesterase 1 (CES1) is the primary enzyme responsible for the bioactivation of ACEI prodrugs in humans. The genetic variant -816A>C (rs3785161) is a common variant located in the promoter region of the...

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PMID: 26915813
DOI: 10.1007/s00228-016-2029-x
PMCID: PMC4865408

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CES1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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