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Article

The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers.

Basic & clinical pharmacology & toxicology - 1 Dec 2017

Stage Claus, Jürgens Gesche, Guski Louise Schow, Thomsen Ragnar, Bjerre Ditte, Ferrero-Miliani Laura, Lyauk Yassine Kamal, Rasmussen Henrik Berg, Dalhoff Kim

Abstract excerpt

This study investigated the influence of variations in the carboxylesterase 1 gene (CES1) on the pharmacokinetics of enalapril. Forty-three healthy, Danish, Caucasian volunteers representing different pre-defined genotypes each received 10 mg of enalapril. At specified time-points, plasma concentrations of enalapril and the active metabolite enalaprilat were measured. The volunteers were divided into six...

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Identifiers

PMID: 28639420
DOI: 10.1111/bcpt.12835

Genes

CES1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers.PMID 28639420Read ↗

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