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Article

Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites.

Biochemical and biophysical research communications - 9 May 2008

Yoshimura Mika, Kimura Tomomi, Ishii Miho, Ishii Keisuke, Matsuura Tadashi, Geshi Eiichi, Hosokawa Masakiyo, Muramatsu Masaaki

Abstract excerpt

Carboxylesterase 1 (CES1) is involved in metabolic activation of a variety of prodrugs into active derivatives and plays an important role in pharmacokinetics. We previously reported that a single nucleotide polymorphism (SNP), -816A/C of the CES1A2 gene associates with the responsiveness to an angiotensin-converting enzyme (ACE) inhibitor, imidapril, whose activity is achieved by CES1. To identify relevant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18328811
DOI: 10.1016/j.bbrc.2008.02.120

Genes

CES1
ACE

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Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites.PMID 18328811Read ↗

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