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Article

Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.

British journal of clinical pharmacology - 1 Dec 2021

Her Lucy H, Wang Xinwen, Shi Jian, Choi Hee Jae, Jung Sun Min, Smith Logan S, Wu Audrey H, Bleske Barry E, Zhu Hao-Jie

Abstract excerpt

AIMS: Enalapril is a prodrug and needs to be activated by carboxylesterase 1 (CES1). A previous in vitro study demonstrated the CES1 genetic variant, G143E (rs71647871), significantly impaired enalapril activation. Two previous clinical studies examined the impact of G143E on single-dose enalapril PK (10 mg); however, the results were inconclusive. A prospective, multi-dose, pharmacokinetics and pharmacodynamics...

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Identifiers

PMID: 33963573
DOI: 10.1111/bcp.14888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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