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Article

Thrombin activation of the factor XI dimer is a multistaged process for each subunit.

Journal of thrombosis and haemostasis : JTH - 1 May 2024

Bar Barroeta Awital, Albanese Pascal, Kadavá Tereza, Jankevics Andris, Marquart J Arnoud, Meijers Joost C M, Scheltema Richard A

Abstract excerpt

BACKGROUND: Factor (F)XI can be activated by proteases, including thrombin and FXIIa. The interactions of these enzymes with FXI are transient in nature and therefore difficult to study. OBJECTIVES: To identify the binding interface between thrombin and FXI and understand the dynamics underlying FXI activation. METHODS: Crosslinking mass spectrometry was used to localize the binding interface of thrombin on FXI....

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Source

Identifiers

PMID: 38242207
DOI: 10.1016/j.jtha.2023.12.038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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