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Article

A sequential mechanism for exosite-mediated factor IX activation by factor XIa.

The Journal of biological chemistry - 2 Nov 2012

Geng Yipeng, Verhamme Ingrid M, Messer Amanda, Sun Mao-fu, Smith Stephen B, Bajaj S Paul, Gailani David

Abstract excerpt

During blood coagulation, the protease factor XIa (fXIa) activates factor IX (fIX). We describe a new mechanism for this process. FIX is cleaved initially after Arg(145) to form fIXα, and then after Arg(180) to form the protease fIXaβ. FIXα is released from fXIa, and must rebind for cleavage after Arg(180) to occur. Catalytic efficiency of cleavage after Arg(180) is 7-fold greater than for cleavage after...

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Identifiers

PMID: 22961984
DOI: 10.1074/jbc.M112.376343
PMCID: PMC3488089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A sequential mechanism for exosite-mediated factor IX activation by factor XIa.PMID 22961984Read ↗

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