Article
Identification of the factor XII contact activation site enables sensitive coagulation diagnostics.
Nature communications - 22 Sept 2021
Heestermans Marco, Naudin Clément, Mailer Reiner K, Konrath Sandra, Klaetschke Kristin, Jämsä Anne, Frye Maike, Deppermann Carsten, Pula Giordano, Kuta Piotr, Friese Manuel A, Gelderblom Mathias, Sickmann Albert, Preston Roger J S, Nofer Jerzy-Roch, Rose-John Stefan, Butler Lynn M, Salomon Ophira, Stavrou Evi X, Renné Thomas
Abstract excerpt
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of recombinant FXII mutants identified a continuous stretch of residues Gln317-Ser339 that was essential for FXII...
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